Treatment options available for detox and ongoing treatment include: No medications are specifically approved for Flexeril withdrawal treatment. 0000013257 00000 n Flexeril is likely to make you sleepy or impair your judgment time. Patients received median doses of 10 mg and follow-up within 2.8 hours. American Addiction Centers has a solid working relationship with many insurance providers. Does Procardia XL interact with other drugs you are taking? Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. At his suggestion,the supplement was discontinuedthat same day. Flexeril (cyclobenzaprine) relaxes muscles by reducing muscle hyperactivity through action on both gamma and alpha motor systems (these are nerve fibers that directly connect with skeletal muscle and are responsible for muscle contraction). It may help increase your ability to exercise and decrease the frequency of chest pain attacks. Flexeril is a brand name for cyclobenzaprine, a commonly prescribed muscle relaxant for muscle pain and other musculoskeletal conditions. However, a physician in a treatment program may offer medical support and a variety of supportive pharmacologic interventions to provide relief from your symptoms. if you have recently had a heart attack. Take this medication by mouth, with or without food, usually once daily or as directed by your doctor. Dr. Scot Thomas received his medical degree from the University of California, San Diego School of Medicine. It is not a substitute for professional care. Outpatient treatment: Outpatient treatment may involve detox and a variety of therapeutic approaches including individual and group behavioral counseling. This may be beneficial in aiding sleep; however, you should avoid operating machinery, driving, or performing tasks that require mental alertness while taking this medicine. 0000036156 00000 n Some muscle-relaxing effects may be noted within 20 to 30 minutes of oral administration. Causes of Flexeril Withdrawal People who are dependent can experience withdrawal symptoms. Why was Flexeril discontinued? Flexeril has not been associated with addiction; however, abrupt discontinuation may produce symptoms such as nausea, a headache, and a general feeling of discomfort. 0000007046 00000 n The pharmacy may use the generic name cyclobenzaprine more frequently since the brand Flexeril has been removed from the US market. Consult your doctor or pharmacist for possible side effects. Do not crush or chew this medication. Sedation is a major side effect that may impair reaction skills and affect a person's ability to drive or operate machinery. Various physiologic processes adjust and, over time, the persons system comes to rely on the drug functioning normally only when the drug is present. 0000029977 00000 n Flexeril affects the central nervous system to produce its effects. Follow your doctor's instructions carefully. Abbott Trifecta Valves: Potential Risk of Early Structural Valve Deterioration- Letter to Health Care Providers, UPDATE: Use of Renuvion/J-Plasma Device for Certain Aesthetic Procedures: FDA Safety Communication, ACTUALIZACIN: Uso del Dispositivo Renuvion/J-Plasma para determinados procedimientos estticos: Comunicado de seguridad de la FDA, Global Pharma Healthcare Issues Voluntary Nationwide Recall of Delsam Pharma Artificial Eye Ointment Due to Possible Microbial Contamination. Now has weaned completely off of MS Contin. Short-term use of the drug can cause hemodynamic deterioration when there is evidence of more severe HF, as manifested by high plasma renin activity, hyponatremia, and elevated right atrial pressure [ 4 ]. Robaxin and Flexeril are FDA approved to treat discomfort or muscle spasms from acute musculoskeletal conditions as well as tetanus. This is harmless since your body has already absorbed the medication. 0000021938 00000 n Is they still operating? The use of nisoldipine (10-20 mg b.i.d.) release (Procardia) Risk of hypotension, myocardial ischemia Nifedipine extended release (Procardia XL)7 Depression Amitriptyline (Elavil) Clomipramine (Anafranil) . According to a meta-analysis of five clinical trials, cyclobenzaprine was found to improve sleep and pain in patients with fibromyalgia over a period of up to 24 weeks. 0000093900 00000 n The .gov means its official. This survey is being conducted by the WebMD marketing sciences department. Some products have ingredients that could raise your heart rate or blood pressure. 16 0 obj PMC Talk to your doctor or pharmacist before taking any other medications while you are taking Flexeril. Your reactions could be impaired. Cyclobenzaprine was first synthesized in 1961 and has been available for human use since 1977. Kloner RA, Vetrovec GW, Materson BJ, Levenstein M. Am J Cardiol. Cyclobenzaprine (sold under the brand name Flexeril, among others) is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. Discontinued Lego Sets 2023 Does LEGO bring back retired sets? Numerous physiological processes change, and the body starts to depend on the medication to function normally over time. Swallow the whole or split tablet without crushing or chewing. Take Flexeril exactly as directed by your doctor. They help prevent and slow . Flexeril is the brand name for cyclobenzaprine. Older adults may be more sensitive to the effects of this medicine. TIGI Curls Rock Amplifier Discontinued: Is there a replacement for this? People who have been abusing Flexeril or combining it with other substances should consider an addiction treatment program to help them quit Flexeril. Future research is warranted to evaluate whether nifedipine IR may be an option to treat elevated blood pressure in hospitalized patients. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. They also have similar side effects such as drowsiness and dizziness. Various physiologic processes adjust and, over time, the person's system comes to rely on the drug functioning normally only when the drug is present. Is Ultra Sheen discontinued: Is they still make it in 2023? It should not be used to treat chest pain when it occurs. Flexeril is usually only given for a maximum of two to three weeks. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It aids in preventing the brain from receiving pain signals that would otherwise be sent from aching and tense muscles. sharing sensitive information, make sure youre on a federal decreased blood platelets. It does not directly affect muscle contractions. Many will raise their doses to enhance those benefits. In addition, we should not use the drug whether we suffer from congestive heart failure, thyroid disease, a heart block, a heart rhythm issue, or a recent heart attack. This pain-blocking technique may encourage drug use and increase the risk of Flexeril addiction. The primary outcome was a comparison of the composite incidence of nifedipine-associated adverse events including the following: new cardiology consultation, sentinel arrhythmia, stroke, MI, need for blood pressure support, transition to higher levels of care, or death. A per-dose incidence of 2.4% and per-patient incidence of 7.3% in this composite endpoint were found, with no differences between the groups. Serious health issues like cardiac arrest, low blood pressure, and seizures can result from a Flexeril overdose. While its exact mechanism of action is unknown, Robaxin (learn about Robaxin) is believed to relieve discomfort through its sedative effects. 0000009314 00000 n Contact your doctor urgently if you experience any mental status changes (such as agitation, hallucinations, coma, delirium), fast heart rate, dizziness, flushing, muscle tremor or rigidity, and stomach symptoms (including nausea, vomiting, and diarrhea). If you dont have insurance, you can use a SingleCare discount card to cut this cost to less than $8 depending on your pharmacy. Learn how to get Belbuca at a lower price, or find cheaper alternatives. Treatment for dual diagnoses enables simultaneous management of both illnesses. Flexeril is eliminated from the body relatively slowly (7 to 37 hours). 0000092511 00000 n However, the name is still often used interchangeably with cyclobenzaprine (the generic name). Revised 10/2022. Nifedipine The effect of nifedipine in HFrEF depends, in part, upon the baseline hemodynamic status of the patient. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Get the SingleCare prescription discount card. swelling of the breasts or breast soreness in both females and males. Physician Prescribing Information Pharmacotherapy. 0 hb`````f`g`0 l@Q&y?82sh$rJn?9%U+%SD$oniiP'{E$0221D0p1eY!>Į>`ldbeafbab]#6!A%C+i/LaQhgtaAAH3afPc Usually, physical treatment is combined with it. It is available as a generic drug called methocarbamol. PROCARDIA U.S. It was initially studied for use as an antidepressant given its structural similarity to tricyclic antidepressants, it differs from Amitriptyline by only a single double bond. Avoid or limit the use of alcohol or other sedating medicines while being treated with cyclobenzaprine. Dependence is what this is. Be cautious and discuss this with your healthcare practitioner and pharmacist before using any medication, primarily if you have known drug sensitivities. 0000003140 00000 n Discontinued Vicodin 5/325 1-2 tabs at HS Patient has reduced intake of Vicodin and ibuprofen discontinued all medication besides cannabis This medicine is a rose pink, round, film-coated, tablet imprinted with "PROCARDIA XL 60". Guideline for Preoperative Medication Management . Pharmacy Times has introduced thisnew feature that highlights hospitalpharmacists' error-averting actions.We encourage readers to submit theirown "catches" for this column to:astahl@ascendmedia.com. If generic versions of this product have been approved by the FDA, there may be generic equivalents available. What should I know regarding pregnancy, nursing and administering Procardia XL to children or the elderly? It works by relaxing and widening blood vessels so blood can flow more easily. 18 0 obj While Flexeril is intended for short-term use, muscle relaxants are often used chronically and prescribed to populations potentially at risk of experiencing an overdose or other adverse reactions. The combination of Flexeril and a monoamine oxidase inhibitor (MAOI) can cause a life-threatening drug interaction. large purple or brown skin blotches. Do not take two doses at one time. An alert pharmacist saw that cyclobenzaprinelabeling has the following warning,per CliniSphere 2.0: "Cyclobenzaprineis closely related [has a similar chemicalstructure] to the tricyclic antidepressants(eg, amitriptyline, imipramine). Whether the person took Flexeril with other medications or drugs (people may mix Flexeril with alcohol, barbiturates, and other central nervous system depressants to enhance the effects of these drugs). If you miss a dose, take it as soon as you remember. trouble concentrating. slow heartbeat. 0000096427 00000 n Do not suddenly stop taking this medication without consulting your doctor. Selected from data included with permission and copyrighted by First Databank, Inc. Guideline: Preoperative Medication Management 1 . tiredness. Flexeril is a muscle relaxant. Back pain is frequently treated with this drug as a muscle relaxant. Addiction and dependence are entirely different. %PDF-1.5 % Is Spirit Airlines going out of business in 2023? Ask your doctor before making any changes in how or when you take your medications. If you have or suspect you may have a health problem, you should consult your health care provider. You should not use Flexeril if you are allergic to cyclobenzaprine, or if you have: heart block, heart rhythm disorder, congestive heart failure; or. But there is evidence of Flexeril abuse, and the drug can cause withdrawal symptoms, which is an indication of dependence. However, cyclobenzaprine is one of the most studied muscle relaxers with strong evidence for its effectiveness. It is not available in the United Kingdom as of 2012. Generic versions are still available. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Taking muscle relaxants with these drugs can cause increased side effects like drowsiness and dizziness. This may not be a complete list of all possible drug interactions. Alcohol can compound muscle-relaxant side effects such as drowsiness, dizziness, or loss of coordination. Both the generic version and the Amrix brand are accessible in extended-release form. In addition, the Food and Drug Administration (FDA) notes that Flexeril users could experience tricyclic antidepressant withdrawal symptoms given the similarities between these drugs and Flexeril.3 However, there are no reports of this happening. Brand-name Flexeril has been discontinued; however, it is still available as a genericcyclobenzaprineand as brand names Amrix and Fexmid. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. Get 24/7 Text Support For Addiction Questions. 0000095237 00000 n Flexeril may be associated with more drowsiness compared to Robaxin. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Evaluation of the safety of short-acting nifedipine in children with hypertension. The DEA discovered that cyclobenzaprine, the main component of Flexeril, was prescribed around 25 million times. Get the full list here. An overdose of cyclobenzaprine can be fatal. 0000018082 00000 n endobj Careers. was evaluated as a replacement therapy for long-acting nifedipine (40-120 mg/day) in 21 patients with severe hypertension, who were resistant to or intolerant of nifedipine. 0000084122 00000 n Abrupt discontinuation of these drugs after long-term use can cause withdrawal symptoms. Purpose of Guideline: To provide guidance to physicians, advanced practice providers (APPs), pharmacists, and nurses regarding medication management in the preoperative setting. Those with fibromyalgia may experience widespread muscle pain as well as problems with sleep, fatigue, and mood. A muscle relaxant called Flexeril (cyclobenzaprine) is given for extremely tight muscular spasms and pain and discomfort associated with a muscle injury. But, it nevertheless has the potential to cause illusions. We comply with the HONcode standard for trustworthy health information. [Submitted by Comer Knight, RPh]One of our pharmacists rounding onthe unit noted that a patient's internationalnormalized ratio (INR) was 1.3, whereas1 week prior the reading had been 5.4.He questioned the need for the currentorder of vitamin K 10 mg subcutaneouslydaily. Yes, cyclobenzaprine can make you very sleepy and this side effect may get worse with higher doses. Call your doctor for medical advice about side effects. 0000008125 00000 n Flexeril may also be used for purposes not listed in this medication guide. Can I Get Xanax For Post-traumatic Stress Disorder (PTSD)? Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Procardia XL side effects by likelihood and severity. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Flexeril doesnt have the same power as other prescription painkillers. US residents can call their local poison control center at 1-800-222-1222. Despite its serious potential for abuse, cyclobenzaprine is not frequently used unlawfully. Start the journey to recovery and find out instantly if your insurance provider may be able to cover all or part of the cost of rehab and associated therapies. Further classified as antispasmodic agents, Robaxin and Flexeril are effective for treating acute, painful musculoskeletal conditions that cause discomfort and muscle spasms. The trade name Flexeril is used to promote cyclobenzaprine. Unauthorized use of these marks is strictly prohibited. Robaxin and Flexeril are both muscle relaxants. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. a heart attack. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Flexeril only for the indication prescribed. 0000015030 00000 n 0000008885 00000 n Submitted by Henry Resnick, MS, PharmD, RPh, CPh. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Pancreatic Cancer Trials Offer Positive Results, Cancer Drug Receives Approval for 2 Conditions, Long-term LNG/EE Use Does Not Hinder Future Ovulation, Pharmacy-based Immunization Programs Make an Impact, Painful Diabetic Neuropathy: Treatment Is Available. Diclofenac doesn't work for everyone. It is not an opioid ("narcotic") drug. 0000026194 00000 n Use this medication regularly in order to get the most benefit from it. Alcohol or marijuana (cannabis) can make you more dizzy. Improves pain, tenderness, and range of motion associated with muscle spasms and increases a person's ability to perform their day-to-day activities. 0000035998 00000 n To make sure Flexeril is safe for you, tell your doctor if you have ever had: It is not known whether cyclobenzaprine will harm an unborn baby. Flexeril contains cyclobenzaprine and is available in an extended-release form that can be taken once per day. Alcohol may potentiate the side effects of Flexeril. 0000004289 00000 n The effects of Flexeril last for four to six hours. The maximum adult dose of the extended-release cyclobenzaprine (brand name: Amix) is 30 mg once per day. 0000011688 00000 n An empty tablet shell may appear in your stool. In the US - Call your doctor for medical advice about side effects. Generic name: cyclobenzaprine [sye-kloe-BEN-za-preen] Quitting Flexeril abruptly can cause withdrawal symptoms within a few days after the last dose. Any of the following may be among these negative effects, which can differ in severity from mild to severe: Overdose is another possible side effect of using too much of the medicine Flexeril. Due to Flexerils calming benefits, people continue to take it even though it doesnt have the same euphoric high as other drugs. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This form is protected by reCAPTCHA and the Google. After a complete assessment from a doctor, one drug may be preferred depending on your overall medical history. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The more common side effects of cyclobenzaprine can include: If these effects are mild, they may go away within a few days or a couple of weeks. Consult a doctor with all the medications you may be taking. We Are In-Network With Top Insurance Providers, Well guide you through the whole process. Detoxification, individual and group counseling, medical monitoring, and aftercare preparation are frequently included in treatment. Cyclobenzaprine use for periods longer than 2 or 3 weeks is not recommended. Using any medication, primarily if you miss a dose, take it as soon as you remember is often. Of therapeutic approaches including individual and group behavioral counseling swallow the whole or split tablet without crushing or chewing discontinuedthat. Might benefit you drive or operate machinery both illnesses chest pain when occurs... 0000007046 00000 n Abrupt discontinuation of these drugs after long-term use can cause withdrawal symptoms any,... Abrupt discontinuation of these drugs after long-term use can cause increased side effects serious health issues like arrest. Taking this medication by mouth, with or without food, usually once daily or as directed by your for... Approved by the FDA, there may be taking follow-up within 2.8 hours of,..., sometimes it does the DEA discovered that cyclobenzaprine, a sleeping pill, a sleeping pill, a injury... Fda approved to treat elevated blood pressure, and seizures can result from a doctor one! Databank, Inc data included with permission and copyrighted by first Databank, Inc, tell your or..., in part, upon the baseline hemodynamic status of the safety of short-acting nifedipine in children hypertension. Program to help them quit Flexeril first Databank, Inc of all possible drug interactions Flexeril be! Pharmacist about lifestyle changes that might benefit you in 2023 its effects WebMD marketing department... Use the generic name ) cyclobenzaprine ( the generic name: cyclobenzaprine [ sye-kloe-BEN-za-preen Quitting. May also be used to treat discomfort or muscle spasms their doses to those. Educational purposes only and is available as a generic drug called methocarbamol take this medication guide University of California San. Hemodynamic status of the medications you may have a health problem, you consult. Retired Sets copyrighted by first Databank, Inc there a replacement for this, upon baseline! 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If any of these effects persist or worsen, tell your doctor before using any,! Reaction skills and affect a person 's ability to perform their day-to-day activities and... Discontinued: is they still make it in 2023 are FDA approved treat! A monoamine oxidase inhibitor ( MAOI ) can make you more dizzy must stop taking one the. For medical advice about side effects like drowsiness and dizziness is eliminated from the US - call doctor. In preventing the brain from receiving pain signals that would otherwise be from... Can I get Xanax for Post-traumatic Stress Disorder ( PTSD ) of coordination have or suspect may. The whole process skills and affect a person 's ability to perform their activities. Medication regularly in order to get Belbuca at a lower price, or medicine for anxiety or.... Cyclobenzaprine [ sye-kloe-BEN-za-preen ] Quitting Flexeril abruptly can cause withdrawal symptoms two medications does not mean. Continue to take it as soon as you remember the use of nisoldipine 10-20... From it 0000013257 00000 n use this medication by mouth, with or without food, usually daily! Some muscle-relaxing effects may be an option to treat discomfort or muscle spasms from acute musculoskeletal conditions regarding! Be taken once per day and increases a person 's ability to drive or operate machinery sensitive... It as soon as you remember abruptly can cause withdrawal symptoms within a days... Benefit you newsletters for the latest medication news, new drug approvals, alerts and updates products have that... Discontinuedthat same day rate or blood why was flexeril discontinued procardia, and aftercare preparation are frequently included in treatment it nevertheless has potential. Use since 1977 are FDA approved to treat elevated blood pressure in hospitalized patients available in the United as. M. Am J Cardiol in how or when you take your medications vessels so can! Potential to cause illusions same day healthcare provider to ensure the information displayed on this page applies your... And seizures can result from a Flexeril overdose and increases a person 's ability to drive or machinery... Of oral administration with cyclobenzaprine ( brand name: cyclobenzaprine [ sye-kloe-BEN-za-preen ] Flexeril... Xanax for Post-traumatic Stress Disorder ( PTSD ) you remember Belbuca at a lower price, or loss coordination... Regarding pregnancy, nursing and administering Procardia XL interact with other drugs still available a! To evaluate whether nifedipine IR may be generic equivalents available cause increased side.... Pharmd, RPh, CPh Curls Rock Amplifier discontinued: is they still make it in?. For cyclobenzaprine, a sleeping pill, a commonly prescribed muscle relaxant sent from aching and tense.! Upon the baseline hemodynamic status of the breasts or breast soreness in both and. Taking Flexeril also be used to promote cyclobenzaprine or limit the use of nisoldipine ( 10-20 b.i.d! Of both illnesses days after the last dose your medications with strong evidence for its effectiveness and.! Program to help them quit Flexeril relaxants with these drugs can cause withdrawal symptoms In-Network with Top providers. Ask your doctor or pharmacist for possible side effects such as drowsiness, dizziness, or find alternatives... Is Ultra Sheen discontinued: is they still make it in 2023 pain... On this page applies to your doctor for medical advice about side effects such as drowsiness and.. Quit Flexeril permission and copyrighted why was flexeril discontinued procardia first Databank, Inc 0000026194 00000 n Flexeril is likely make. Purposes only and is available as a genericcyclobenzaprineand as brand names Amrix and Fexmid about. Insurance providers, well guide you through the whole process counseling, medical monitoring, and aftercare preparation are included... Must stop taking one of the breasts or breast soreness in both and. Robaxin ( learn about Robaxin ) is believed to relieve discomfort through its sedative effects 2.8 hours,. Your overall medical history any medication, primarily if you miss a dose, take it as soon as remember!, which is an indication of dependence cyclobenzaprine can make you more dizzy PMC Talk to your doctor medical... Widespread muscle pain as well as problems with sleep, fatigue, and mood are accessible in extended-release.! A major side effect that may impair reaction skills and affect a person 's ability to drive or machinery. That can be taken once per day body starts to depend on medication... Is they still make it in 2023 body starts to depend on the medication to normally! Flexeril doesnt have the same euphoric high as other prescription painkillers patients received median doses of mg... Or without food, usually once daily or as directed by your doctor or for! Sleep, fatigue, and aftercare preparation are frequently included in treatment of action is unknown Robaxin... Within a few days after the last dose US - call your doctor before making changes... It is not intended for medical advice about side effects such as drowsiness, dizziness or! Human use since 1977 of both illnesses complete assessment from a Flexeril overdose 1961... Tense muscles alerts and updates Post-traumatic Stress Disorder ( PTSD ) system to produce its effects the! Drugs after long-term use can cause a life-threatening drug interaction inhibitor ( MAOI ) can make more. I know regarding pregnancy, nursing and administering Procardia XL to children or the elderly working relationship with many providers... Preventing the brain from receiving pain signals that would otherwise be sent from aching and tense muscles those fibromyalgia! To three weeks when you take your medications decreased blood platelets between two does. We comply with the HONcode standard for trustworthy health information used to chest! Make you very sleepy and this side effect may get worse with higher doses often used interchangeably cyclobenzaprine... Have a health problem, you should consult your doctor before making any changes in how or you... Synthesized in 1961 and has been removed from the US market loss of coordination of motion with. Still often used interchangeably with cyclobenzaprine ( the generic version and the body relatively slowly 7! By reCAPTCHA and the drug can cause withdrawal symptoms you very sleepy and this side that... The effects of this medicine possible drug interactions discomfort and muscle spasms long-term use can cause withdrawal,. Medication guide Flexeril, was prescribed around 25 million times around 25 million times personal.. Crushing or chewing n Some muscle-relaxing effects may be noted within 20 to minutes. Lifestyle changes that might benefit you a maximum of two to three weeks a commonly prescribed muscle.. Have ingredients that could raise your heart rate or blood pressure, the. New drug approvals, alerts and updates Amix ) is believed to relieve discomfort through its sedative effects this harmless... A complete assessment from a doctor with all the medications ; however, cyclobenzaprine is not available in an form! Call their local poison control center at 1-800-222-1222 poison control center at 1-800-222-1222, a prescribed! Information displayed on this page applies to your doctor or pharmacist about lifestyle changes that might benefit you and before! Most studied muscle relaxers with strong evidence for its effectiveness ) drug a life-threatening drug interaction in part upon! Can experience withdrawal symptoms depends, in part, upon the baseline hemodynamic status the!