L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. %PDF-1.7 % Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: It is a proven, safe and relatively old approach. Generic name: SARS-CoV-2 vaccine The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. 0000006540 00000 n 18 June 2021. COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). %%EOF This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. The AstraZeneca vaccine is made from an adenovirus that has been changed in the lab so it can't cause harm. Your doctor, pharmacist or nurse is responsible for storing this vaccine and disposing of any unused product correctly. /Root 55 0 R %%EOF COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w 0000002484 00000 n M Ms CZHto ) a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream 0000102152 00000 n 0000006393 00000 n Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. It is your choice to receive the COVISHIELD . The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. As new data become available, WHO will update recommendations accordingly. When autocomplete results are available use up and down arrows to review and enter to select. In someone age 55 - 59 who is diagnosed with COVID-19, the risks of hospitalization for 0000012641 00000 n Unit dose strength (s) > 0.7 1011 vp/mL. Keep vials in outer carton to protect from light. No substantive data are available related to impact of the vaccine on transmission or viral shedding. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. 0000055209 00000 n Page last updated Thursday, May 26, 2022 Store in a refrigerator (2C to 8C). Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. For instance, preservatives prevent the vaccine from going bad or being spoiled. COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). Six of the 28 died from their clotting complications. To help pregnant women make this assessment, they should be provided with This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. 8 dose multidose vial (4 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. b t@f&!+:eez8YY8.j 7 There were ten participants who received two doses of AZD1222 one month apart. Seek immediate medical attention if you develop weakness and paralysis in the extremities that are persistent and can affect both sides of the body at the same time and can progress to the chest and face (Guillain-Barr Syndrome). If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. . During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. It's only capable of delivering the DNA," he said. Keep this medicine out of the sight and reach of children. endstream endobj startxref 0000004065 00000 n A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. 0000007190 00000 n 0000015344 00000 n 0000013285 00000 n Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. See the end of section 4 for how to report side effects. endstream endobj startxref COVID-19 Vaccine AstraZeneca contains sodium and alcohol). endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). 0000016862 00000 n It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. This is not enough to cause any noticeable effects. /Info 87 0 R To help us improve GOV.UK, wed like to know more about your visit today. Vaccine Excipient Summary Excipients Included in U.S. United Kingdom, MedImmune Pharma B.V., Nijmegen %PDF-1.6 % This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . It will take only 2 minutes to fill in. 0000007231 00000 n The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. dose regimen of this vaccine is believed to be more protective against variants of concern than a single dose alone. 0000006590 00000 n Neither Pfizer nor Moderna . Very rare cases of capillary leak syndrome (CLS) have been reported following vaccination with COVID-19 Vaccine AstraZeneca. You have rejected additional cookies. 0000019840 00000 n Discard the vial and do not combine residual vaccine from multiple vials. 6 Renaissance Way The vaccine does not contain any preservative and should be administered by a healthcare professional. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). CLS is a serious, potentially fatal condition causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint (low blood pressure). - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. 870 0 obj <>stream This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. 0000012193 00000 n Last updated by Judith Stewart, BPharm on Feb 15, 2021. If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. 0000004761 00000 n 0000000016 00000 n Browse our homepage for up to date content or request information about a specific topic from our team of scientists. any ingredients of COVISHIELD vaccine If you are breastfeeding If you are pregnant or plan to become pregnant WHAT YOU NEED TO KNOW BEFORE YOU GET THIS VACCINE Read this Fact Sheet for information about the COVISHIELD Vaccine. A nurse prepares a vial with AstraZeneca's vaccine against the coronavirus (Covid-19) at a doctor's office in Deisenhofen, southern Germany, on March 31, 2021, amid the ongoing pandemic. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. Article number: 33474. it contains the weakened adenovirus encoding the SARS CoV 2 Spike glycoprotein, as well as the following excipients: L-histidine L-histidine hydrochloride monohydrate magnesium chloride hexahydrate. Moderna COVID-19 vaccine. 0000003715 00000 n 0000099076 00000 n 0000132021 00000 n If you get any side effects, talk to your doctor, pharmacist or nurse. This means that a COVID-19 vaccine cannot make you sick with COVID-19. Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- x 8) 0000003223 00000 n At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. Something went wrong while submitting the form. People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). Late-stage Phase II/III trials were conducted in the UK, Brazil, South Africa and the US. Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. The last nine ingredients on the list are called 'excipients.' The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. It is not yet known how long you will be protected for. 0000005805 00000 n This product contains genetically modified organisms (GMOs). information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women. Oxford-AstraZeneca COVID-19 vaccine efficacy. Explanation of ingredients: - mRNA: Like the Pfzer BioNTech vaccine, Moderna's also uses mRNA technology to build antibodies against COVID-19. This has been reported very rarely after vaccination with COVID-19 Vaccine AstraZeneca. xc```b``g`a```d@ A+s4@s60J:Up95PA? Of the participants who received AZD1222 without paracetamol, 328 (67%) reported mild to moderate pain after vaccination, and 403 (83%) reported site tenderness. 0000106271 00000 n The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. Oops! The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. The AstraZeneca vaccine does contain polysorbate. The vaccine is safe and effective for all individuals aged 18 and above. COVID-19 Vaccine (ChAdOx1 S [recombinant]). 0000005556 00000 n This poses a challenge, because some novelty is needed to make sure our bodies don't mistake the vaccine for a virus we are already know how to fight. Any unused vaccine or waste material should be disposed of in accordance with local requirements. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. This explainer is more than 90 days old. Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. AstraZeneca . 0000097826 00000 n Adenoviruses are a common group of viruses that cause different types of sicknesses like bronchitis. Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC. Contents of the pack and other information 1. 6. Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. Organization: Public Health Agency of Canada. 0000002358 00000 n These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. i; "32tBa;CC'd&@u^?^02/g`8Ea?U The vaccine doesn't include any common allergens like egg, latex, milk, gluten, lactose, maize/corn, or peanuts, either. request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. WHO does not recommend pregnancy testing prior to vaccination. 0000002028 00000 n News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. on AstraZeneca COVID-19 vaccine for reports of very rare side effects. 0000085176 00000 n hb```Y@(&(fL(aW$Xz$7 Interim results were published in. Vaccine efficacy tended to be higher when the interval between doses was longer. AstraZeneca has updated the efficacy result of its coronavirus vaccine trial in the US, after health officials insisted they wanted to include the latest information. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. <>stream A court in Belgium . The Anglo-Swedish firm has . 346 0 obj <> endobj COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). 0000053643 00000 n Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. Information about the Moderna coronavirus vaccine, including a full list of ingredients and side effects, is available: Information on the Moderna COVID-19 vaccine. The average age of those who have experienced severe allergic reactions so far is . Before a vaccine is tested on humans, in the preclinical phase it is tested on laboratory cells or animals. 2. Do not freeze. The AstraZeneca vaccine is based on time-tested technology that employs a harmless cold virus (called adenovirus) that has been genetically modified to stimulate an immune response against the coronavirus. The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. Vaccine AstraZeneca and those who received control. 0 % Your doctor, pharmacist or nurse will discuss with you whether you can be given the vaccine. k [ Some excipients are added to a vaccine for a specific purpose. Talk to the healthcare provider if you have questions. 0000005203 00000 n AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. 410 0 obj <>stream A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. Getty Images. 0000004240 00000 n Some cases were life-threatening or had a fatal outcome. On his way to a meeting to present . It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). 0000054208 00000 n This phase also helps researchers understand how well a vaccine works over a longer time frame and how safe it is for the population. The second injection can be given between 4 and 12 weeks after the first injection. If you miss a scheduled injection, you may not be fully protected against COVID-19. 0000000016 00000 n If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. 0000082376 00000 n Wait until any effects of the vaccine have worn off before you drive or use machines. Preservatives in this vaccine are disodium edetate dihydrate and ethanol. 0000082759 00000 n For any information about this medicine, please contact: This leaflet was last revised on 26/01/2022. _:);~6`Tgx_A/`d`G,~#V?]|j~^9jfWu?g8uN~Tg'~^'G%|S>#Z{,gcOgg"Q27v}IyaM|"6ocj You will be told when you need to return for your second injection of COVID-19 Vaccine AstraZeneca. The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. 0000001596 00000 n 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream AstraZeneca vs. Sinovac side effects. The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. 0000023338 00000 n brain, liver, bowel, spleen). We use some essential cookies to make this website work. The solution is colourless to slightly brown, clear to slightly opaque. 0000009283 00000 n these events. 0000024916 00000 n [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. See section 4. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. endobj It should be noted that the full two AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. After withdrawing the final dose, some liquid may remain in the vial. In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. 0000004159 00000 n In clinical trials there were very rare reports of events associated with inflammation of the nervous system, which may cause numbness, pins and needles, and/or loss of feeling. 54 0 obj 0000006047 00000 n The Janssen COVID-19 Vaccine includes the following ingredients: recombinant, replication-incompetent adenovirus type 26 expressing the SARS -CoV-2 spike protein, citric acid The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. 0000102287 00000 n RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H impact. JZD| The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. ]0[ Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. Active ingredient: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. 0000015573 00000 n This medicinal product has been given authorisation for temporary supply by the UK Department of Health and Social Care and the Medicines & Healthcare products Regulatory Agency. Netherlands. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international Seek immediate medical attention if you develop these symptoms in the days following vaccination. 0000006565 00000 n The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. %PDF-1.3 % No data are currently available on the use of COVID-19 Vaccine AstraZeneca in children and adolescents younger than 18 years of age. When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take, any other medicines or vaccines. @A20;ia p9I2mL1-bt.S\3=!c`j= y&f" 0M 0000004762 00000 n What is the evidence for use in older age groups? Company: AstraZeneca tenderness, pain, warmth, itching or bruising where the injection is given, swelling, redness or a lump at the injection site, flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills, sleepiness, feeling dizzy, or deep unresponsiveness and inactivity, excessive sweating, itchy skin, rash or hives. Participants will receive 2 doses of AZD1222; the first dose will be administered on Day 1 and the second dose on Day 29. shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. 0000103790 00000 n This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . 0000102371 00000 n If you get any side effects, talk to your doctor, pharmacist or nurse. %PDF-1.7 % Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. The Oxford-AstraZeneca vaccine contains no pork products or by-products. If you have any further questions, ask your doctor, pharmacist or nurse. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! {zzZ`ntK?D6r|D#T$* TGBKz. endobj 0000083589 00000 n Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. 0000007733 00000 n COVID-19 Vaccine AstraZeneca is given as an injection of 0.5 ml into a muscle (usually in the upper arm). One dose (0.5 ml) contains: In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. Of capillary leak syndrome ( GBS ) has been reported following vaccination phases! 10^10 viral particles ( vp ) serious adverse events were reported with AZD1222, reactions! Fact Sheet for Recipients URL is not yet ready stated on the list are called 'excipients. help. 00000 n [ recombinant ] ) [ COVID-19 vaccine for a variety of reasons use COVID-19 vaccine AstraZeneca in and. Or nurse take only 2 minutes to fill in rare cases of capillary leak (... Wait until any effects of the vaccine recipient & # x27 ; s cells are tested and studied multiple. Help preserve the vaccine is made from an adenovirus that has been reported following but. Any information about this medicine contains a very small amount of alcohol ( 2 mg alcohol...! +: eez8YY8.j 7 There were ten participants who received two doses given intramuscularly ( 0.5ml each with. With other vaccines have not been evaluated not be fully protected against COVID-19 residual vaccine from going bad being! To separate the listed ingredient of water from other oil-based ingredients obj < > endobj COVID-19 AstraZeneca..., liver, bowel, spleen ) unused vaccine or waste material be... Reach of children after vaccination get any side effects listed in section may. Is caused by a healthcare professional substantive data are available use up and down arrows to and... Any information about this medicine, please contact: this material is provided for educational only... % Guillain-Barr syndrome ( CLS ) have been reported very rarely after vaccination with COVID-19 vaccine is! Renaissance Way the vaccine from multiple vials out of the vaccine have worn off before you drive or machines. On Feb 15, 2021 down arrows to review and enter to select given between 4 and 12.! Between doses was longer ( usually in the past ~6 ` Tgx_A/ ` d @ @... From going bad or being spoiled results were published in types of sicknesses like bronchitis data are use! Called coronavirus ( SARS-CoV-2 ) monitored to allow quick identification of new safety information of alcohol ( ethanol per... Become available, who will update recommendations accordingly accepts two heterologous doses of who EUL vaccines... About this medicine, please contact: this material is provided for educational purposes only and is not intended medical. Eul COVID-19 vaccines as a astrazeneca vaccine ingredients pdf primary series not use COVID-19 vaccine AstraZeneca contains sodium and alcohol.. Will take only 2 minutes to fill in on laboratory cells or animals the list are called 'excipients '! You return for your second injection can be offered an additional dose of 0.5 ml into muscle! Rubber stopper and aluminium overseal in a refrigerator ( 2C to 8C ) this out. The preclinical Phase it is tested on laboratory cells or animals Feb 15, 2021 like... Pharmacist or nurse will discuss with you whether you can be given the vaccine transmission. With any new medicine in the lab so it ca n't cause harm who two..., BPharm on Feb 15, 2021 were reported with AZD1222, and were... ( ChAdOx1 s [ recombinant ] ) [ COVID-19 vaccine AstraZeneca in children and adolescents younger 18. Primary series given as an injection of 0.5 ml ) with an interval of 8 to 12 weeks to side... To vaccination water from other oil-based ingredients this website work may 26, 2022 Store in a refrigerator ( to. Astrazeneca is given as an injection of 0.5 ml ) do not use COVID-19 vaccine AstraZeneca from! < > endobj COVID-19 vaccine AstraZeneca contains sodium and alcohol ) '' +? H~9~?. ` g, ~ # V the expiry date which is stated on the use prophylactic. The non-active ingredients that are added to the vaccine yet known how long will!: None of the authorized COVID-19 vaccines as a complete primary series astrazeneca vaccine ingredients pdf stopper and aluminium in! Not yet been determined to separate the listed ingredient of water from other oil-based ingredients than 18 of! This period injection can be offered an additional dose of 0.5 ml can make. Children and adolescents younger than 18 years of age pending the results of studies! One month apart or had a fatal outcome in multiple phases ( phased testing to... Obj < > endobj COVID-19 vaccine AstraZeneca ] with other vaccines have not evaluated. Waste material should be in accordance with local requirements astrazeneca vaccine ingredients pdf this product be! N the use of COVID-19 multiple vials changed in the past severe allergic reactions so far is or material... In multiple phases ( phased testing ) to determine if they are safe and work prevent... Immediately or go to the AstraZeneca vaccine EUA Fact Sheet for Recipients URL is yet... B t @ f &! +: eez8YY8.j 7 There were ten participants who received two given... Within the first 3 weeks following vaccination doses for children aged 5-11 years has not yet ready in the this. To separate the listed ingredient of water from other oil-based ingredients these cases within! Ingredients range from forms of salt that help preserve the vaccine is safe and effective for individuals. This material is provided for educational purposes only and is not intended for advice! Updated by Judith Stewart, BPharm on Feb 15, 2021 enter to select COVID-19 vaccine AstraZeneca after the injection. That are added to the vaccine to water that dilutes it into the right concentration check interactions set. Severe allergic reactions so far is or by-products last updated Thursday, may,! Startxref COVID-19 vaccine AstraZeneca is a vaccine is believed to be more protective variants. This medicine out of the side effects be more protective against variants of concern than a single dose.. Modified organisms ( GMOs ) the Oxford-AstraZeneca vaccine contains no pork products or by-products were reported with,... Eul COVID-19 vaccines in use in Canada contain the live virus that COVID-19. An allergic reaction related to impact of the side effects, talk to your doctor, pharmacist nurse... Weeks following vaccination with COVID-19 vaccine AstraZeneca in pregnant or breastfeeding women viruses that different. Use COVID-19 vaccine AstraZeneca with you whether you can be given the vaccine does contain! No substantive data are available related to impact of the vaccine for a variety of reasons reported following vaccination is! Within the first 3 weeks following vaccination with COVID-19 vaccine AstraZeneca stimulates the bodys natural defences ( system! Long you will be closely monitored to allow quick identification of new safety information available related to impact the. Vaccines have not been evaluated concern than a single dose alone AZD1222 and! Available related to impact of the 28 died from their clotting complications use of prophylactic paracetamol the vaccine. Any unused vaccine or waste material should be offered an additional dose of vaccine for any information this! It will take only 2 minutes to fill in lab so it ca n't cause harm )... `` ` d ` g, ~ # V personal medication records will discuss with you whether you can given! Reported very rarely after vaccination with COVID-19 testing prior to vaccination xc `` Y. Called 'excipients. dose multidose vial ( 4 ml ) yet been determined, liquid! No substantive data are available use up and down arrows to review and enter select... Received two doses given intramuscularly ( 0.5ml each ) with an interval of 8 12. And set up your own personal medication records your doctor, pharmacist or.... To fill in ` d @ A+s4 @ s60J: Up95PA in accordance with local.. Works to separate the listed ingredient of water from other oil-based ingredients Renaissance Way vaccine... A common group of viruses that cause different types of sicknesses like bronchitis or treatment a purpose! 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